Fifteen-Year Follow-up of Hyperoxaluria Type II

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To the Editor: Type II primary hyperoxaluria was first described by Williams and Smith in 1968 in four patients, three of whom were siblings.1 We report the progress of these three cases after 15 years.Patient 1, born in 1955, the older brother of the two other siblings, passed two calcium oxalate stones at the age of two. An intravenous urogram revealed renal-tract calculi bilaterally. The patient underwent pyelolithotomy, but no biochemical cause for stone formation was found, and it was not until 1961 that a diagnosis of hyperoxaluria was made. The disease did not behave like the Type I . . .

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