Palladium-catalysed carbonyl allylation by isoprene via regioselective 1,4-addition of tin hydride formed in situ

Abstract
Isoprene reacts with aldehydes in the presence of a catalytic amount of Pd(OAc)2–4PPh3 or Pd(PPh3)4 and a stoichiometric amount of SnCl2 at 40–50 °C in AcOH–H2O to produce 1-substituted 2,2-dimethyl-3-buten-1-ols regioselectively.

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