Preferential Uptake of14C-α-Aminoisobuturic Acid into Mouse Uterine Tissue during Early Pregnancy

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Abstract
Mice in experimentally delayed implantation were given estrogen and 14C-AIB [.alpha.-aminoisobutunic acid] at different time intervals. Mice in delayed implantation given on 14C-AIB displayed a low transport rate into the uterine tissue, comparable with that for the diaphragm muscle. If the estrogen injection preceeded that of the 14C-AIB by 4-8 h, the transport capacity increased by a factor of at least 4 times while the uptake for the diaphragm muscle remained low. Under such condition 14C-AIB-accumulation into uterine tissue was favored for at least 4 h of in vivo incubation with the labeled amino acid.