Prostaglandin Stimulation of Rat Corticosteroidogenesis
- 14 February 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 163 (3868) , 691-692
- https://doi.org/10.1126/science.163.3868.691
Abstract
Prostaglandins and their C20:ω6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE1, PGE2, or PGF1∞ 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3', 5'-cyclic monophosphate; all three responses were inhibited by cycloheximide.Keywords
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