Correlation between sex hormones, thyroid hormones and desoxycorticosterone as judged by their effects on the weights of organs of gonadectomized rats

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Abstract
In 168 adult gonadectomized [male] and [female] rats the following hormones were administered: androsterone 4.5 mg. (per wk.), testosterone propionate 0.75 mg., estradiol benzoate-butyrate 0.015 and 0.09 mg., desoxycorticosterone acetate 2-4 mg. (also tablets of this hormone were implanted subcut.), desiccated thyroid powder 90-480 mg., thyroxine sodium 1-3 mg. A co-operative stimulating effect on the wt. and size of the organs was recorded between estrogenic and thyroid hormones in the case of [female] sex organs, liver, kidneys and (less definitely) heart and spleen. Hypertrophy of the adrenals was also greater with these 2 hormones than with either hormone alone. Co-operative effect was also noted between the [male] androsterone and thyroid hormones in [female][female], or desoxycorticosterone and thyroid hormones on the wt. and size of liver, kidneys, heart and, less constantly, spleen, but not on sex organs. Desoxycorticosterone, injected alone, produced only a slight increase in wt. of kidney and liver. Hypertrophy of the adrenals and retardation of body growth produced by thyroid hormones was decreased when [male] hormones were given simultaneously, the latter exerting a partial neutralizing (antagonistic) action on these effects of thyroid hormones.