Mode of Action of Thyrocalcitonin1

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Abstract
Thyrocalcitonin was given to rats 2.5 hr. after injecting 45Ca intravenously. The normal continuous fall in specific activity of blood Ca was interrupted by the action of thyrocalcitonin but there was no effect on the disappearance of radio-Ca from the circulation even though serum Ca fell 30-50%. The data were analyzed with a computer program encompassing a model of Ca exchange with compartments arranged in series. The model adequately reproduced the experimental results which led to the conclusion that thyrocalcitonin acts by inhibiting resorption of Ca from bone.