Development of Sensitivity to Tetrodotoxin in Beating Chick Embryo Hearts, Single Cells, and Aggregates
- 16 June 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4040) , 1248-1250
- https://doi.org/10.1126/science.176.4040.1248
Abstract
The spontaneous activity of intact embryonic heart becomes progressively more sensitive to tetrodotoxin block with increasing age of the embryo. The activity of isolated single heart cells in culture was relatively insensitive, independent of embryo age. Aggregates formed from single cells responded to tetrodotoxin in the same manner as intact hearts; aggregated cells from older hearts were sensitive.Keywords
This publication has 21 references indexed in Scilit:
- Development of sensitivity to tetrodotoxin of chick embryonic hearts with ageJournal of Molecular and Cellular Cardiology, 1971
- Two Inward Currents in Frog Atrial MuscleThe Journal of general physiology, 1971
- The potassium-sensitivity of isolated embryonic heart cells increases with developmentDevelopmental Biology, 1970
- The Ionic Basis of Electrical Activity in Embryonic Cardiac MuscleThe Journal of general physiology, 1968
- Pharmacological Modifications of the Sodium Channels of Frog NerveThe Journal of general physiology, 1968
- Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue cultureDevelopmental Biology, 1967
- Basis of Tetrodotoxin's Selectivity in Blockage of Squid AxonsThe Journal of general physiology, 1967
- Effect of Tetrodotoxin on Membrane Currents in Mammalian Cardiac FibresNature, 1967
- Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant AxonsThe Journal of general physiology, 1964
- Rotation-mediated histogenetic aggregation of dissociated cellsExperimental Cell Research, 1961