SIMULATION OF THE NORMAL MENSTRUAL CYCLE IN KALLMAN'S SYNDROME BY PULSATILE ADMINISTRATION OF LUTEINIZING HORMONE-RELEASING HORMONE (LHRH)

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Abstract
The administration of small doses of LHRH at 2-hourly intervals over a 27 day period to a 24-year old patient with Kallman's syndrome resulted in ovulation as indicated by: (1) a biphasic temperature response, (2) anatomical changes in the ovaries demonstrated by ultrasound, and (3) the pattern of circulating gonadotropin and gonadal steroid concentrations.