Short (And Shorter) Courses of Zidovudine

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Abstract
In this issue of the Journal, Wade and colleagues1 present data on the outcomes of short, prophylactic courses of zidovudine administered to infants born to women infected with the human immunodeficiency virus (HIV) who presented for obstetrical care in New York State between 1995 and 1997. Their report contains some reassuring and confirmatory information, as well as some surprising and provocative new observations. The pathophysiologic and therapeutic basis for the study involves both the timing of the vertical transmission of HIV and the prophylactic role of zidovudine in this setting.One of the earliest clues to the timing of mother-to-infant . . .