The Insulin-Like Growth Factor Axis
Top Cited Papers
- 4 February 2000
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 86 (2) , 125-130
- https://doi.org/10.1161/01.res.86.2.125
Abstract
—Insulin-like growth factors I and II (IGF-I and -II) and their regulatory proteins are secreted by cells of the cardiovascular system. They are growth promoters for arterial cells and mediators of cardiovascular disease. IGFs are bound to IGF binding proteins (IGFBPs), which modulate IGF ligand-receptor interaction and consequently to IGF action. IGFBPs are in turn posttranslationally modulated by specific proteases. This dynamic balance (IGFs, IGFBPs, and IGFBP proteases) constitutes the IGF axis and ultimately determines the extent of IGF-dependent cellular effects. Dysregulated actions of this axis influence coronary atherosclerosis through effects on vascular smooth muscle cell growth, migration, and extracellular matrix synthesis in the atherosclerotic plaque. IGF-I promotes macrophage chemotaxis, excess LDL cholesterol uptake, and release of proinflammatory cytokines. Endothelial cells also receive the effects of IGFs stimulating their migration and organization forming capillary networks. ...Keywords
This publication has 62 references indexed in Scilit:
- Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.Journal of Clinical Investigation, 1997
- Coordinate expression of the insulin-like growth factor system after microembolisation in porcine heartCardiovascular Research, 1997
- Insulin-like growth factor binding protein (IGFBP) proteases: Functional regulators of cell growthProgress in Growth Factor Research, 1995
- Insulin-like growth factor binding protein proteolysis in bone cell modelsProgress in Growth Factor Research, 1995
- Vascular smooth muscle cells synthesize two forms of insulin‐like growth factor binding proteins which are regulated differently by the insulin‐like growth factorsJournal of Cellular Physiology, 1993
- Cloning and sequence determination of bovine insulin‐like growth factor binding protein‐2 (IGFBP‐2): Comparison of its structral and functional properties with IGFBP‐1Journal of Cellular Biochemistry, 1992
- Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)Progress in Growth Factor Research, 1991
- Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.Hypertension, 1991
- Growth factors in pathogenesis of coronary arterial restenosisThe American Journal of Cardiology, 1991
- Distinct receptors for IGF-I, IGF-II, and insulin are present on bovine capillary endothelial cells and large vessel endothelial cellsBiochemical and Biophysical Research Communications, 1984