Minimum effective intensity of oral anticoagulant therapy in primary prevention of coronary heart disease.
Open Access
- 11 September 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 160 (16) , 2462-2468
- https://doi.org/10.1001/archinte.160.16.2462
Abstract
THERE IS mounting evidence that low-intensity oral anticoagulation is effective, particularly in primary prevention,1 with important implications for safety and the practicalities of using warfarin. It is therefore desirable to determine its possible benefit for different indications so that optimal therapy can be administered in as wide a range of conditions as possible. Because of the variability of the effect of anticoagulant therapy, it is difficult to study the optimal intensity of anticoagulation in a randomized manner2; therefore, observational studies (both follow-up and case-control) are necessary. Results of these studies have shown different optimal ranges in different conditions.3This publication has 1 reference indexed in Scilit: