THE EFFECTS OF CARBUTAMIDE (BZ-55) ON BLOOD SUGAR LEVELS OF DEPANCREATIZED DOGS GIVEN INSULIN1

Abstract
SEVERAL recent reports (1, 2, 3) have indicated that administration of BZ-55 (p-amino-benzene-sulphonamide-n-butyl-urea) results in a fall of blood sugar of normal human subjects and various experimental animals. This material does not lower the blood sugar of pancreatectomized dogs, rabbits or alloxanized rats, and results in hypoglycemia only in certain human diabetics. On the basis of evidence obtained both in vitro and in vivo, Mirsky et al. (4, 5, 6) have put forward the hypothesis that the sulfonyl hypoglycemic derivatives act by inhibiting hepatic insulinase. Further, these workers (4) have postulated that human diabetes is not necessarily a resultant of insulin deficiency but may be rather a consequence of increased insulin destruction, presumably by the hepatic insulinase system. While the available evidence strongly suggests that the sulfonyl derivatives act to increase the net amount of functioning insulin, the mechanism by which this is achieved remains unknown.

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