Quantitative Studies on the Neutralization of Pathogenic Agents in Tissues by Circulating Antibodies

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Abstract
Summary: The amount of intravenously injected antitoxin which is necessary to neutralize 10 lethal doses of tetanus toxin, injected intracerebrally, differs in rabbits and guinea pigs even when the difference between the volumes of the plasma of the two animal species is taken into consideration. In the case of diphtheric toxin, however, the values are the same when a correction is made for the volumes of the plasma. The cerebral capillaries of the guinea pig and rabbit, therefore, must be equally permeable to antibodies, contrary to the conclusions existing in the literature. These results also show that the widely held opinion of the impermeability of the cerebral capillaries to antibodies is not tenable.

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