Cyclic AMP receptor protein interacts with lactose operator DNA
- 24 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 9 (2) , 277-292
- https://doi.org/10.1093/nar/9.2.277
Abstract
The wildtype lac promoter-operator region of E.coli was reinvestigated for cyclic AMP receptor protein (CRP) binding sites using the “footprinting’ method. Two distinct interaction sites were found, one in the −60 base pair region, which has previously been described, and a second one covering the lac operator. These two sites are similar in extent, orientation and the characteristic pattern of CRP-induced DNaseI enhanced cutting sites.Keywords
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