THE USE OF SELECTIVE ANGIOGRAPHY TO STUDY THE EFFECTS OF HISTAMINE ON THE DOG'S CARDIOVASCULAR SYSTEM

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Abstract
Selective angiography was utilized to study the effect of histamine on the cardiovascular system of the dog. Histamine caused a decrease in volume of the left heart and caliber of the entire aorta and its major branches (brachiocephalic, celiac, superior mesenteric, renal, and iliac arteries). The femoral arteries and the larger pulmonary veins were also diminished in size. The small vessels of the pulmonary circulation increased in size as did the smaller peripheral arteries of the lower extremities. The intracerebral arteries appeared to constrict and decreased jugular vein opacification following injection of contrast material in the carotid artery was noted. The coronary arteries were intensely opacified and sharply defined. Histamine produced little change in blood volume. The intra-aortic pressure, after a temporary slight rise, decreased for approximately 30 seconds and then gradually returned to normal. Angiography is a useful method in the investigation of the effects of drugs on the circulatory system.