An in vivo study of benzene metabolite DNA adduct formation in liver of male New Zealand rabbits
- 1 May 1989
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 63 (3) , 209-213
- https://doi.org/10.1007/bf00316370
Abstract
Rabbits were treated with benzene (586 mg/kg/ b.i.d./4 days) after which DNA was isolated from liver and analyzed for adduct formation using the [32P] postlabeling method of Randerath and coworkers (Randerath et al. 1981; Reddy et al. 1984, 1986, 1987). Liver 500 g and 9000 g fractions were analyzed for adducts. There appeared to be several adducts in both the 500 g and 9000 g fractions observed on radioautographs of cellulose-TLC plates. Several adducts were also observed when the 9000 g fraction was studied using HPLC.This publication has 26 references indexed in Scilit:
- 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin CMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1987
- Nuclease P1-mediated enhancement of sensitivity of 32P-Postlabeling test for structurally diverse DNA adductsCarcinogenesis: Integrative Cancer Research, 1986
- Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinoneToxicology Letters, 1985
- Inhibition of rna synthesis by benzene metabolites and their covalent binding to dna in rabbit bone marrow mitochondria in vitroAmerican Journal of Industrial Medicine, 1985
- Covalent binding of benzene and its metabolites to DNA in rabbit bone marrow mitochondria in vitroChemico-Biological Interactions, 1984
- 32P-Postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agentsCarcinogenesis: Integrative Cancer Research, 1984
- Effects of enzyme induction on microsomal benzene metabolismJournal of Toxicology and Environmental Health, 1983
- Mechanism of the carcinogenic action of benzene: Irreversible binding to rat liver DNAChemico-Biological Interactions, 1977
- Benzene metabolism in mouse liver microsomesToxicology and Applied Pharmacology, 1973
- The metabolism of benzene in vitroToxicology and Applied Pharmacology, 1967