Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction
- 1 April 1993
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 67 (4) , 2381-2384
- https://doi.org/10.1128/jvi.67.4.2381-2384.1993
Abstract
Competitive polymerase chain reaction was used to quantitate latent varicella-zoster virus (VZV) DNA in human trigeminal ganglia. Ganglionic DNA from five subjects was amplified with oligonucleotide primers specific for VZV gene 28. Two of the samples were also analyzed with primers specific for VZV gene 62. Our results indicated that there are 6 to 31 copies of the VZV genome in every 100,000 ganglionic cells. ImagesKeywords
This publication has 9 references indexed in Scilit:
- Varicella-Zoster Virus Reactivation without RashThe Journal of Infectious Diseases, 1992
- Localization of herpes simplex virus and varicella zoster virus DNA in human gangliaAnnals of Neurology, 1992
- Latent Varicella–Zoster Viral DNA in Human Trigeminal and Thoracic GangliaNew England Journal of Medicine, 1990
- Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.Proceedings of the National Academy of Sciences, 1990
- The Complete DNA Sequence of Varicella-Zoster VirusJournal of General Virology, 1986
- Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humansJournal of Virology, 1986
- Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell AnemiaScience, 1985
- Varicella-zoster viral glycoproteins analyzed with monoclonal antibodiesJournal of Virology, 1984
- The Nature of Herpes Zoster: A Long-Term Study and a New HypothesisProceedings of the Royal Society of Medicine, 1965