Genes Encoding Subunits of Stable Complexes Are Clustered on the Yeast Chromosomes
Open Access
- 1 August 2004
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 167 (4) , 2121-2125
- https://doi.org/10.1534/genetics.103.024505
Abstract
Genomic evidence for colocalization of functionally related genes on eukaryote chromosomes is mounting. Here we show that a statistically significant fraction of yeast genes coding for subunits of stable complexes are located within 10–30 kb of each other. Clustering of genes encoding subunits of complexes may ensure better coregulation and maintain the right stoichiometry of complexes upon duplication of chromosomal segments.Keywords
This publication has 20 references indexed in Scilit:
- Dosage sensitivity and the evolution of gene families in yeastNature, 2003
- Genomic Gene Clustering Analysis of Pathways in EukaryotesGenome Research, 2003
- Evidence for co-evolution of gene order and recombination rateNature Genetics, 2003
- Yeast genome duplication was followed by asynchronous differentiation of duplicated genesNature, 2003
- The Constraints Protein–Protein Interactions Place on Sequence DivergenceJournal of Molecular Biology, 2002
- MIPS: a database for genomes and protein sequencesNucleic Acids Research, 2002
- Relating Whole-Genome Expression Data with Protein-Protein InteractionsGenome Research, 2002
- A computational analysis of whole-genome expression data reveals chromosomal domains of gene expressionNature Genetics, 2000
- Gene structure and organization in Caenorhabditis elegansCurrent Opinion in Genetics & Development, 1996
- A Model of a Genetic System which Leads to Closer Linkage by Natural SelectionEvolution, 1956