Fibrinogen in cryoprecipitate and its relationship to factor VIII (AHF) levels

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Abstract
Very little has been published to indicate the quantity of fibrinogen in cryoprecipitates. Preparations (88) from 5 blood banks were assayed for [human] factor VIII(AHF) and fibrinogen to assess whether the AHF assay can predict fibrinogen content. Cryoprecipitate was considered consistent with FDA [Food and Drug Administration] standards with 80 units of factor VIII/bag (40% yield from 200 ml plasma). Fibrinogen was considered adequate if 200 mg were recovered (40% yield, 200 ml plasma, normal range 150-350 mg/dl). The mean AHF was 145 units/bag and fibrinogen was 266 mg/bag. There was a wide range among bags. In 64/88 bags, the fibrinogen and AHF were concordant, but in 24/88 bags the results were discordant. Although apparently safe to conclude that a bag of cryoprecipitate will average 250 mg fibrinogen, adequate control may require separate assays for fibrinogen.