A Progressive Immunization Reaction in the Actively Sensitized Rabbit Eye

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Abstract
Summary: The injection of adequate amounts of crystalline egg albumin into the vitreous body of the rabbit eye forms a depot of antigen which leaks out of the site only slowly. Antigen is thus present during the development of a hypersensitive state in the animal, giving rise to a “spontaneous” inflammatory response in the uvea after a lag of about a week. This inflammation is characterized by an infiltration of mononuclear cells. Evidence is presented that the hypersensitivity state responsible for this ocular inflammation is systemic, and that the inflammation starts in the majority of cases at least one or more days before the appearance of detectable circulating antibody. The significance of these data with respect to a delayed hypersensitivity mechanism for this ocular inflammation is discussed as is the relationship of this experimental model to the “progressive immunization reaction” of Gell and Hinde.

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