Common Hypothalamic Sites for Activation of Sexual Receptivity in Female Rats by LHRH, PGE2 and Progesterone

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Abstract
Intrahypothalamic infusion of luteinizing hormone-releasing hormone (LHRH) facilitated lordosis responding in ovariectomized rats primed with estrogen (s.c.) and tested with male rats. A high degree of correlation exists in the hypothalamic sites responding to LHRH and estradiol or progesterone. Prostaglandin E2 was highly effective in inducing sexual behavior in rats not only at sites that yielded lordosis to LHRH, but also at sites unresponsive to LHRH. Our results suggest a common region of action in the hypothalamus for LHRH, estradiol and progesterone for the facilitation of lordosis and a ‘supernormal stimulus’ action of prostaglandin E2 throughout most of the mediobasal hypothalamic area for the facilitation of this response.

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