Copper IUD-Induced Loss of Endometrial Arylamidase Activity in the Rabbit

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Abstract
Cu IUD [intrauterine device] of blastocyst size caused, in the rabbit uterine epithelium, local reduction of activity of amino acid arylamidase, an aminopeptidase type enzyme found in the endometrium and in uterine secretion during preimplantation phases. By this means (although evidently by a different mechanism, i.e., direct enzyme inhibition) Cu IUD mimicked an effect exerted by the late preimplantation and early implantation stage blastocyst which locally stimulated discharge of this enzyme from the uterine epithelium into the uterine secretion. The effect was not seen in experiments with Cu-free IUD and hormone-containing IUD.

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