Characterizationof Murine Leukemia Virus Restriction inMammals
Open Access
- 15 December 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (24) , 13403-13406
- https://doi.org/10.1128/jvi.77.24.13403-13406.2003
Abstract
Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.Keywords
This publication has 23 references indexed in Scilit:
- Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factorsNature Medicine, 2003
- Abrogation of Ref1 Retrovirus Restriction in Human CellsJournal of Virology, 2002
- A conserved mechanism of retrovirus restriction in mammalsProceedings of the National Academy of Sciences, 2000
- Use of a Transient Assay for Studying the Genetic Determinants of Fv1 RestrictionJournal of Virology, 2000
- Single Amino Acid Changes in the Murine Leukemia Virus Capsid Protein Gene Define the Target ofFv1ResistanceVirology, 1996
- Operating under a Gag Order: a Block against Incoming Virus by the Fv1 GeneCell, 1996
- Positional cloning of the mouse retrovirus restriction gene FvlNature, 1996
- Synthesis and circularization of N- and B-tropic retroviral DNA Fv-1 permissive and restrictive mouse cells.Proceedings of the National Academy of Sciences, 1980
- The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus ReplicationPublished by Springer Nature ,1979
- A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSESThe Journal of Experimental Medicine, 1971