Development and Regression of Shope Papillomas Induced in Newborn Domestic Rabbits

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Abstract
Newborn domestic rabbits were inoculated at birth with Shope papil-loma virus and kept under observation for more than 6 months. Over 16 weeks were required for spontaneous regression and such was observed in only 7 out of 55 animals (13%). Serum antibodies against the papilloma virus and cells were elicited in these animals and skin reaction of the delayed type was also elicited against the virus. The low regression rate was not attributed, therefore, to immunological tolerance against the papilloma. Multiple papillomas were produced in some of the animals, but neither infectivity nor virus particles were detected in the papillomas.

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