Neonatal Codeine Withdrawal in Infants of Nonaddicted Mothers

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Abstract
The problem of neonatal narcotic withdrawal has been well described.1-4 The extensive literature on this topic has predominantly described infants of chronically addicted mothers. In many instances the mother's addiction is well known; ideally, when appropriate communication has taken place between obstetric and neonatal personnel, the latter can anticipate a problem in the infant and be prepared to treat accordingly. We have recently managed two infants with classic manifestations of withdrawal following maternal use of codeine-containing medications by nonaddicted mothers prior to delivery. Each infant was initially sent to a regular newborn nursery. In each instance, there was a significant delay before the diagnosis of withdrawal was considered.
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