Studies of the Persorption of Large Particles from Radio-Labelled Cation Exchangers

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Abstract
Experiments were carried out in pigs to ascertain to what extent the cation exchangers Ujolyt and Campanyl used in the prevention of urinary stones [in humans] undergo persorption and appear in the urine. Two preparations of different grain size were used and were detected by labeling with 35S. A maximum of 0.5% or 5 .times. 10-3 of the dose was found as persorbed particles at 51 h, chiefly in the muscles. The number of persorbed particles from the fine-grained preparation was considerably greater than that from the coarse-grained product. The urine contained the smallest proportion of particles, < 2 .times. 10-5 of the dose. Apparently, solid particles persorbed during treatment with ion exchange resins cannot act as crystallization centers for stone formation, and it is equally unlikely that ion exchangers have to reach the urine before they can exert their effect.

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