Cardiomyopathy Associated with Clozapine

Publisher Website
Google Scholar
Abstract
Objective: To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class. Case Summary: A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy. Discussion: The literature concerning cardiorespiratory complications with clozapine therapy is reviewed. Conclusions: Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.