Myotrophic Activity of 19-Nortestosterone and Other Steroids Determined by Modified Levator Ani Muscle Method.

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Abstract
An 8 day rat levator ani muscle assay was used for screening a number of steroids for myotropic activity. The wt. of the levator ani muscle increases linearly with the log of the dose of testosterone propionate. Myotropic/ androgenic ratios (m/a ratios) for steroids are computed as the levator ani increase/ventral prostate increase. The m/a ratios for testosterone, testosterone propionate, and methylandrostenediol ranged from 0.16 to 0.32. 19-Nortestosterone and other 19-nor analogues of androgens were found to have m/a ratios of 1.0 and 2.0 indicating high myotropic activity and low androgenic activity.