The Metabolic Fate of Prolan in a Dilan-Resistant Strain of House Flies

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Abstract
A susceptible laboratory strain of houseflies (Musca domestica L.), exhibited resistance to Dilan (1 part 1,1-bis(p-chlorophenyl)-2 -nitropropane and 2 parts (1,1-bis(p-chlorophenyl)-2- nitrobutane) after several generations of selection pressure with that insecticide. Resistance to the Prolan®(1,1-bis(p-chlorophenyl)- 2-nitropropane) component of Dilan was much more Pronounced than that to the Bulan® (1,1-bis(p-chlorophenyl)-2- nitrobutane) component or to Dilan. Metabolism tests showed that 75 to 94% of the 8 micro grams of Prolan appliedwasrecoveredfrom2 to 120 hours after topical treatment of female resistant flies. At 24 and 48 hours, 42.5and 62.8% of the dosage applied was absorbed by the insect. Two compounds were detected in the excreta of treated flies: (1) A neutral material, soluble in common organic solvents, similar to prolan in infrared, ultraviolet, and colorimetric spectra, and almost as toxic to mosquito larvae as the parent compound, and (2) an acidic material, extractable with dilute alkali, different from Prolan in photometric spectra and chemical properties (showing loss of No2 group in the propane moiety), and much less toxic to mosquito larvae. Excretion of the toxic metabolite appeared to be more important to the fly's survival in the initial stages of poisoning

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