Conversion of 1,2,5,6-Dibenzanthracene by Rabbits, Rats, and Mice. Significance in Carcinogenesis of this Conversion

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Abstract
From the extracts of excreta of rabbits, rats, and mice injected with 1,2,5,6-dibenzanthracene, substances of a phenolic nature were isolated which are considered to be conversion products of dibenzanthracene. The substance isolated from injected rabbits was non-carcinogenic and gave absorption bands different from those of the substance obtained from injected rats and mice. This fact suggests that different species metabolize dibenzanthracene differently. The absorption bands of unchanged dibenzanthracene were present in the fraction containing neutral compounds of feces of injected rats, mice, and rarely of rabbits.

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