EPSP synthase inhibitor deisgn III. Synthesis & evaluation of a new 5-oxamic acid analog of EPSP which incorporates a malonate ether as a 3-phosphate mimic
- 1 December 1993
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 3 (12) , 2857-2862
- https://doi.org/10.1016/s0960-894x(01)80779-4
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Steady-State Kinetic Evaluation of the Reverse Reaction for Escherichia coli 5-enolpyruvoylshikimate-3-phosphate SynthaseArchives of Biochemistry and Biophysics, 1993
- EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics.Bioorganic & Medicinal Chemistry Letters, 1993
- (Z)-3-Fluorophosphoenolpyruvate as a pseudosubstrate of EPSP synthase: enzymatic synthesis of a stable fluoro analog of the catalytic intermediateJournal of the American Chemical Society, 1992
- Substrate synergism and the steady-state kinetic reaction mechanism for EPSP synthase from Escherichia coliBiochemistry, 1992
- Inhibition of 5-enolpyruvoylshikimate 3-phosphate (EPSP) synthase by analogs of the tetrahedral intermediate and of EPSPJournal of the American Chemical Society, 1992
- Synthesis and evaluation of two new inhibitors of EPSP synthaseTetrahedron Letters, 1991
- Kinetic and structural analysis of enzyme intermediates: lessons from EPSP synthaseChemical Reviews, 1990
- A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kineticsBiochemistry, 1988
- Isolation and structural elucidation of the tetrahedral intermediate in the EPSP synthase enzymic pathwayJournal of the American Chemical Society, 1988
- The Site of the Inhibition of the Shikimate Pathway by GlyphosatePlant Physiology, 1980