Palladium-Catalyzed C−H Homocoupling of Thiophenes: Facile Construction of Bithiophene Structure
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- 31 March 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (16) , 5074-5075
- https://doi.org/10.1021/ja031855p
Abstract
Palladium-catalyzed C−H homocoupling of thiophene derivatives takes place in the presence of silver(I) fluoride or acetate. A variety of bithiophenes are obtained in good to excellent yields. In particular, the reaction of 2-bromothiophene proceeds at room temperature to afford 5,5‘-dibromo-2,2‘-bithiophene, where the bromine atom is completely intact in the palladium-catalyzed reaction. XRD analysis reveals that silver fluoride is reduced to silver(0) during the reaction.Keywords
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