Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors
- 22 June 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (16) , 4347-4351
- https://doi.org/10.1016/j.bmcl.2004.05.090
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transferProceedings of the National Academy of Sciences, 2003
- Two-Repeat Human Telomeric d(TAGGGTTAGGGT) Sequence Forms Interconverting Parallel and Antiparallel G-Quadruplexes in Solution: Distinct Topologies, Thermodynamic Properties, and Folding/Unfolding KineticsJournal of the American Chemical Society, 2003
- The structure of telomeric DNACurrent Opinion in Structural Biology, 2003
- The Design of G-quadruplex Ligands as Telomerase InhibitorsMini-Reviews in Medicinal Chemistry, 2003
- Telomeres and telomerases as drug targetsCurrent Opinion in Pharmacology, 2002
- Crystal structure of parallel quadruplexes from human telomeric DNANature, 2002
- Telomere maintenance as a target for anticancer drug discoveryNature Reviews Drug Discovery, 2002
- Natural and pharmacological regulation of telomeraseNucleic Acids Research, 2002
- Fluorescence Resonance Energy Transfer as a Probe for G-Quartet Formation by a Telomeric RepeatChemBioChem, 2001
- Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplexStructure, 1993