Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation
- 1 March 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 258 (2) , 529-533
- https://doi.org/10.1042/bj2580529
Abstract
We investigated temporal relationship between hepatic glycogen depletion and cardiac and hepatic PDH (pyruvate dehydrogenase complex) activities during the acute phase of starvation. There was a striking correlation between the decline in hepatic glycogen and PDH inactivation during the first 10 h of starvation. Re-feeding after 6 h starvation was associated with complete re-activation of PDH in liver and re-activation to approx. 75% of the fed value in heart, whereas in rats previously starved for 24-48 h re-activation was delayed in liver and diminished in heart. The results are discussed with reference to the fate of dietary carbohydrate after re-feeding.This publication has 28 references indexed in Scilit:
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