1-Alphahydroxycholecalciferol in Chronic Renal Failure
- 1 March 1976
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 84 (3) , 281-285
- https://doi.org/10.7326/0003-4819-84-3-281
Abstract
Four patients with advanced chronic renal failure and osteodystrophy were treated with 1-.alpha.-hydroxycholecalciferol, a synthetic vitamin D analogue, in a daily oral dose of 1.5-2.0 .mu.g, for periods up to 1 yr. They showed increased Ca absorption, positive Ca and P balances, moderate increases in serum Ca levels, marked reductions in serum alkaline phosphatase levels, a decrease in serum immunoreactive parathyroid hormone levels and radiologic and histologic improvement in bone disease. One patient with proximal myopathy showed improvement in muscular strength. 1-.alpha.-hydroxycholecalciferol appears to be effective therapy for renal osteodystropy.Keywords
This publication has 1 reference indexed in Scilit:
- 1,25 Dihydroxy-Vitamin D_3 in Normal Man and Patients with Renal FailureAnnals of Internal Medicine, 1974