Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion
- 1 February 1994
- journal article
- case report
- Published by Wiley in American Journal of Hematology
- Vol. 45 (2) , 187-188
- https://doi.org/10.1002/ajh.2830450218
Abstract
We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO.Keywords
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