A Mechanism of AZT Resistance
Open Access
- 1 July 1999
- journal article
- research article
- Published by Elsevier in Molecular Cell
- Vol. 4 (1) , 35-43
- https://doi.org/10.1016/s1097-2765(00)80185-9
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT): Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse TranscriptaseBiochemistry, 1998
- Pre-Steady-State Kinetic Characterization of Wild Type and 3‘-Azido-3‘-deoxythymidine (AZT) Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Implication of RNA Directed DNA Polymerization in the Mechanism of AZT ResistanceBiochemistry, 1997
- Single-Step Kinetics of HIV-1 Reverse Transcriptase Mutants Responsible for Virus Resistance to Nucleoside Inhibitors Zidovudine and 3-TCBiochemistry, 1997
- Nucleotide-Induced Stable Complex Formation by HIV-1 Reverse TranscriptaseBiochemistry, 1997
- 2′,3′-Dideoxynucleoside triphosphates (ddNTP) and di-2′,3′-dideoxynucleoside tetraphosphates (ddNp4ddN) behave differently to the corresponding NTP and Np4N counterparts as substrates of firefly luciferase, dinucleoside tetraphosphatase and phosphodiesterases1Dedicated to our friend, Professor Claudio Fernández de Heredia, on his 65th birthday.1Biochimica et Biophysica Acta (BBA) - General Subjects, 1997
- Comparative Enzymatic Study of HIV-1 Reverse Transcriptase Resistant to 2‘,3‘-Dideoxynucleotide Analogs Using the Single-Nucleotide Incorporation AssayBiochemistry, 1997
- Sensitivity of HIV-1 Reverse Transcriptase and Its Mutants to Inhibition by Azidothymidine TriphosphateBiochemistry, 1994
- Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptaseBiochemistry, 1991
- Molecular Targets for AIDS TherapyScience, 1990
- The Accuracy of Reverse Transcriptase from HIV-1Science, 1988