Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma
- 15 July 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 206 (1) , 181-184
- https://doi.org/10.1042/bj2060181
Abstract
A specific 1,25-dihydroxycholecalciferol-binding protein has been detected in high-salt cytosols prepared from human medullary thyroid carcinomas. The binding protein had the same equilibrium dissociation constant (Kd = 0.17 +/- 0.05 nM; n = 4) and sedimentation coefficient on sucrose gradients (3.7S) as than seen in established vitamin D target tissues. This protein was not detected in normal thyroid cytosols, which may reflect the low proportion of C-cells within the gland.This publication has 20 references indexed in Scilit:
- Organ Distribution of the Cytoplasmic 1,25- Dihydroxycholecalciferol Receptor in Various Mouse Tissues*Endocrinology, 1980
- Unoccupied 1,25-dihydroxyvitamin D3 receptors. Nuclear/cytosol ratio depends on ionic strength.Journal of Biological Chemistry, 1980
- Biochemical evidence for 1, 25-dihydroxyvitamin D receptor macromolecules in parathyroid, pancreatic, pituitary, and placental tissuesLife Sciences, 1980
- CALCITONIN AND 1,25-DIHYDROXYVITAMIN D3 RECEPTORS IN HUMAN-BREAST CANCER CELL-LINES1980
- Basic and Clinical Concepts Related to Vitamin D Metabolism and ActionNew England Journal of Medicine, 1977
- Lack of Effect of Calcitonin on the Regulation of Vitamin D Metabolism in the Rat1Endocrinology, 1977
- Effect of Calcitonin on Vitamin D MetabolismNature, 1972
- Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid GlandsProceedings of the National Academy of Sciences, 1972
- The cytochemistry of the thyroid C cells and their relationship to calcitoninProceedings of the Royal Society of London. B. Biological Sciences, 1966
- Histogenesis of medullary carcinoma of the thyroidJournal of Clinical Pathology, 1966