HLA A*, B*‐BF* AND C4 A*, ALLELE ASSOCIATIONS, WITH SPECIAL REFERENCE TO BF*S07, IN THE TUNISIAN POPULATION

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Abstract
The HLA A*2, Bw*50‐BF*S07‐C4 A*2, B*l linkage group was transmitted unambiguously in four unrelated Tunisian families. In one of these, another allele association, also carrying BF*S07, HLA A*9, Bw*50‐BF* S07‐C4 A*1, B*1, was encountered. The previously reported linkage disequilibrium between BF*S07 and HLA Bw*50, a subtypic speficity of HLA Bw*21, is confirmed in our study. The C4 A*2, B*1, haplotype, rare in the other populations until now studied, seems more frequent in Tunisia since it has been also found linked to HLA A* 11, B*27 and BF*S in one of these familie. Other allele associations were unambiguously demonstrated with predominantly the C4 A*3, B*1 haplotype, particularly a rare HLA A*3, B*18‐BF* F1‐C4 A*3, B*1 linkage group. A silent gene at the C4 A locus was found linked to HLA B*.

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