Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac
- 1 April 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (4) , 589-591
- https://doi.org/10.1021/jm00154a027
Abstract
The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (1) is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.This publication has 2 references indexed in Scilit:
- Synthesis, antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compoundsJournal of Medicinal Chemistry, 1985
- Synthesis of optically active forms of methyl (E)-2,4,5-tetradecatrienoate, the pheromone of the male dried bean beetleTetrahedron, 1981