Effect of Glucagon on Renal Functions in the Dog.

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Abstract
Glucagon given by continuous intravenous infusion at 6 to 45 jig/min-ute, or by single intravenous or intraperitoneal injection (0.2 to 0.5 mg) increased glomerular filtration rate on the average from 59.9 to 75.2 ml/min. in 26 experiments in 7 dogs and increased renal plasma flow from 190 to 256 ml/min. in 14 experiments in 3 dogs. Filtration fraction did not change. Route of administration, the vehicle and rate of infusion within limits tested did not affect the results. The maximum ability of the renal tubules to reabsorb glucose was not altered significantly in 11 experiments in 7 dogs. Daily administration of glucagon for 140 and 145 days in 2 dogs did not produce sustained increases in renal functions.

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