HL-A Antigen W27 — A Genetic Link between Ankylosing Spondylitis and Reiter's Syndrome?

Abstract
To the Editor: Recent publications have reported the association between HL-A antigen W27 and ankylosing spondylitis1 , 2 and Reiter's syndrome,3 4 5 We are in a position to confirm these observalions: 53 primary cases of ankylosing spondylitis (44 in males) fulfilling the Rome criteria and 46 cases of Reiter's syndrome (43 in males) with seronegative arthritis in conjunction with germ-free urethritis, all while, were studied with use of microlymphocytotoxicity against 27 HL-A specificities. W27 frequency was found in 81 and 80 per cent of the eases respectively in the two groups of patients, as opposed to 4 per cent of the cases in . . .

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