L-Methionine Enhances the Contractile Responses of Rat Uterine Smooth Muscle to Acetylcholine and High KCl
Open Access
- 1 January 1986
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 40 (3) , 469-471
- https://doi.org/10.1254/jjp.40.469
Abstract
The contractile responses of isolated uterine smooth muscle from estradiol-treated ovariectomized rats to acetylcholine and high KCl in Ca-depleted modified Locke-Ringer (without CaCl2 and with 0.1 mM EGTA) solution on addition of CaCl2 (final concentration, 5 mM) are used as an indicator of Ca influx through the Ca channel. L-Methionine significantly enhanced these responses in the absence and presence of 3-deazaadenosine plus homocysteine thiolactone, blockers of methylation. These findings suggest that methylations of some components in isolated uterine smooth muscle seem to be important in stimulation contraction coupling in the muscle.This publication has 6 references indexed in Scilit:
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