Relaxant Drugs in Cerebral Palsy: 1949–1960

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Abstract
DRUG therapy in cerebral palsy is an accepted component of the over-all treatment plan. A drug may be primarily effective as an anticonvulsant, as a neuromotor relaxant or as a behavior ameliorator. Whereas the effectiveness of anticonvulsant medication is proved, the evidence of the benefits of drugs that modify neuromotor and behavioral deviations is not clear cut.In 1942 interest in a "drug approach" to cerebral palsy was stimulated by the apparent beneficial neuromotor and behavioral effects in 6 spastic children of a combination of curare and amphetamine.1 In 1949, when mephenesin was studied against placebo for effectiveness as a . . .

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