Synthesis of (4E)-9-deoxy-6,9α-epoxy-Δ4-PGF, a prostacyclin (PGX) isomer

Abstract
(4E)-9-Deoxy-6,9α-epoxy-Δ4-PGF, a prostacyclin (PGX) isomer, has been synthesized from PGF methyl ester by a novel PhSeCl-induced cyclization.