Dioncophylline A, the Principal Cytotoxin fromAncistrocladus letestui

Abstract
Using bioassay-guided fractionation, dioncophylline A [1] was isolated from the leaves and twigs of the tropical liana Ancistrocladus letestui Pelligr. Dioncophylline A was previously known from Triphyophyllum peltatum and A. abbreviatus. The in vitro cytotoxicity profile of 1 was characterized against the NCI panel of human tumor cell lines.

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