Conformational analysis of lipophilic antifolates: crystal structure of piritrexim and a theoretical evaluation of its binding to dihydrofolate reductase
- 1 August 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 110 (18) , 6219-6224
- https://doi.org/10.1021/ja00226a042
Abstract
No abstract availableThis publication has 15 references indexed in Scilit:
- Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A QSAR and graphics analysisJournal of Medicinal Chemistry, 1986
- Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by MutagenesisScience, 1986
- Lone-pair directionality in hydrogen-bond potential functions for molecular mechanics calculations: the inhibition of human carbonic anhydrase II by sulfonamidesJournal of the American Chemical Society, 1985
- A computational procedure for determining energetically favorable binding sites on biologically important macromoleculesJournal of Medicinal Chemistry, 1985
- Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.Journal of Biological Chemistry, 1985
- Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.Journal of Biological Chemistry, 1985
- Protein dynamicsReports on Progress in Physics, 1984
- Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.Journal of Biological Chemistry, 1982
- BIOCHEMICAL AND CHEMOTHERAPEUTIC STUDIES ON 2,4-DIAMINO-6-(2,5-DIMETHOXYBENZYL)-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (BW 301U), A NOVEL LIPID-SOLUBLE INHIBITOR OF DIHYDROFOLATE-REDUCTASE1982
- INHIBITION OF HISTAMINE-METABOLIZING ENZYMES AND ELEVATION OF HISTAMINE LEVELS IN TISSUES BY LIPID-SOLUBLE ANTI-CANCER FOLATE ANTAGONISTS1980