Abstract
Many theoretical papers investigating the relationship between chromosomal change and speciation are found to have been based on erroneous data. For rather than considering those negatively heterotic, or at least potentially negatively heterotic rearrangements which can have a possible role in speciation, these papers have included substantial amounts of information on rearrangements which are not implicated in this process. Common forms of chromosomal repatterning such as heterochromatic addition and polymorphism are in this category. Their inclusion in theoretical studies, often cited as supporting or opposing a chromosomal involvement in speciation, invalidates these findings. A new approach is suggested.