A reaction associated with nonenzymatic binding in the reticulocyte transfer system.

Abstract
A reaction of the reticulocyte transfer system leading to resistance to inhibition by NaF and associated with chain initiation is described. Rabbit liver S-RNA was used. The reaction was dependent upon 1 or more soluble factors in added enzyme fractions and upon sulfhydryl compounds. The reaction was dependent upon but distinguishable from nonenzymatic binding. It was not dependent upon added GTP. It is suggested that the formation of an active complex involving ribosomes, messenger RNA, amino-acyl-sRNA, and 1 or more soluble transfer enzymes is involved.

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