Determination of enantiomeric excess by 13C NMR spectroscopy
- 1 October 1984
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Chemistry
- Vol. 22 (10) , 624-628
- https://doi.org/10.1002/mrc.1270221006
Abstract
Oxazolidine derivatives of β‐amino alcohols such as ephedrine have been resolved by 13C NMR spectroscopy using Eu(hfc)3 as a chiral shift reagent. The method is quantitative in the determination of enantiomeric excess, and is advantageous where 1H NMR is of limited use owing, for example, to significant line broadening.Keywords
This publication has 6 references indexed in Scilit:
- Spectres RMN-13C DE β-Aminoalcools Derives DE L'Ephedrine ET De Leurs OxazolidinesAnalytical Letters, 1979
- NMR determination of the enantiomer composition of penicillamine using an optically active europium shift reagentMagnetic Resonance in Chemistry, 1974
- Determination of optical purity with chiral shift reagents and 13C magnetic resonanceJournal of Magnetic Resonance (1969), 1973
- Modern Methods for the Determination of Optical PurityPublished by Wiley ,1967
- Reaction of ephedrine with chloroformJournal of Pharmacy and Pharmacology, 1964
- Isotropic Nuclear Resonance ShiftsThe Journal of Chemical Physics, 1958